{"id":256,"date":"2026-07-02T15:33:49","date_gmt":"2026-07-02T15:33:49","guid":{"rendered":"https:\/\/genhelixoptima.com\/?post_type=product&#038;p=256"},"modified":"2026-07-16T11:58:51","modified_gmt":"2026-07-16T11:58:51","slug":"glp-3-rt","status":"publish","type":"product","link":"https:\/\/genhelixoptima.com\/en\/product\/glp-3-rt\/","title":{"rendered":"GLP-3 RT"},"content":{"rendered":"<div class=\"et_pb_section_0 et_pb_section et_section_regular et_block_section\">\r\n\r\n<div class=\"et_pb_row_0 et_pb_row et_flex_row\">\r\n\r\n<div class=\"et_pb_column_0 et_pb_column et-last-child et_flex_column et_pb_css_mix_blend_mode_passthrough et_flex_column_24_24 et_flex_column_24_24_tablet et_flex_column_24_24_phone\">\r\n\r\n<div class=\"et_pb_tabs_0 et_pb_tabs et_pb_module\"><ul class=\"et_pb_tabs_controls clearfix\"><li class=\"et_pb_tab_nav_item_0 et_pb_tab_nav_item et_pb_tab_0 et_pb_tab_active\"><a class=\"et_pb_tab_nav_item_link\" href=\"#\">DESCRIPTION<\/a><\/li><li class=\"et_pb_tab_nav_item_1 et_pb_tab_nav_item et_pb_tab_1\"><a class=\"et_pb_tab_nav_item_link\" href=\"#\">CERTIFICAT<\/a><\/li><li class=\"et_pb_tab_nav_item_2 et_pb_tab_nav_item et_pb_tab_2\"><a class=\"et_pb_tab_nav_item_link\" href=\"#\">TECHNICAL DATAS<\/a><\/li><li class=\"et_pb_tab_nav_item_3 et_pb_tab_nav_item et_pb_tab_3\"><a class=\"et_pb_tab_nav_item_link\" href=\"#\">STORAGE<\/a><\/li><\/ul><div class=\"et_pb_all_tabs\">\r\n\r\n<div class=\"et_pb_tab_0 et_pb_tab clearfix et_pb_active_content et_pb_module et_flex_module\"><div class=\"et_pb_tab_content et_flex_module\">\r\n\r\n<div class=\"et_pb_code_0 et_pb_code et_pb_module\"><div class=\"et_pb_code_inner\"><style>\n.gh-desc { font-family: 'Montserrat', sans-serif; max-width: 760px; }\n\n.gh-desc__intro {\n  font-size: 15px;\n  font-weight: 500;\n  color: #444455;\n  line-height: 1.9;\n  margin: 0 0 40px;\n}\n\n.gh-desc__intro strong { color: #393089; font-weight: 700; }\n\n.gh-desc__section { margin-bottom: 44px; }\n\n.gh-desc h2.gh-desc__h2 {\n  font-size: 17px;\n  font-weight: 800;\n  letter-spacing: .03em;\n  text-transform: uppercase;\n  color: #393089;\n  margin: 0 0 22px;\n  padding-bottom: 12px;\n  border-bottom: 2px solid #E8E2F5;\n}\n\n.gh-desc h3.gh-desc__h3 {\n  display: flex;\n  align-items: center;\n  gap: 10px;\n  font-size: 12.5px;\n  font-weight: 800;\n  letter-spacing: .08em;\n  text-transform: uppercase;\n  color: #5D378D;\n  margin: 28px 0 12px;\n}\n\n.gh-desc h3.gh-desc__h3:first-of-type { margin-top: 0; }\n\n.gh-desc h3.gh-desc__h3::before {\n  content: '';\n  width: 16px;\n  height: 2px;\n  background: #9065A8;\n  border-radius: 2px;\n  flex-shrink: 0;\n}\n\n.gh-desc__text {\n  font-size: 13.5px;\n  font-weight: 500;\n  color: #555568;\n  line-height: 1.9;\n  margin: 0 0 8px;\n}\n\n.gh-desc__list {\n  margin: 0;\n  padding: 0;\n  list-style: none;\n}\n\n.gh-desc__list li {\n  position: relative;\n  padding-left: 22px;\n  font-size: 13.5px;\n  font-weight: 500;\n  color: #555568;\n  line-height: 1.85;\n  margin-bottom: 14px;\n}\n\n.gh-desc__list li::before {\n  content: '';\n  position: absolute;\n  left: 0;\n  top: 8px;\n  width: 6px;\n  height: 6px;\n  border-radius: 50%;\n  background: #9065A8;\n}\n\n.gh-desc__refs {\n  margin: 0;\n  padding: 0;\n  list-style: none;\n  border-top: 1px solid #EAE4F5;\n  padding-top: 24px;\n}\n\n.gh-desc__refs li {\n  font-size: 12px;\n  font-weight: 500;\n  color: #6A6A78;\n  line-height: 1.8;\n  margin-bottom: 16px;\n  padding-left: 22px;\n  text-indent: -22px;\n}\n\n.gh-desc__refs strong { color: #393089; font-weight: 700; }\n\n.gh-desc__disclaimer {\n  margin-top: 40px;\n  padding: 16px 18px;\n  background: #F7F5FD;\n  border-left: 3px solid #393089;\n  border-radius: 6px;\n  font-size: 11.5px;\n  font-weight: 600;\n  color: #6A6A78;\n  line-height: 1.8;\n}\n<\/style>\n\n<div class=\"gh-desc\">\n\n  <p class=\"gh-desc__intro translation-block\"><strong>GLP-3 RT<\/strong> (LY3437943) is a synthetic peptide acting as a triple agonist, simultaneously targeting GLP-1, GIP, and GCG receptors. This combined action on three distinct metabolic pathways makes it one of the most currently studied compounds in research on energy metabolism and body weight.<\/p>\n\n  <div class=\"gh-desc__section\">\n    <h2 class=\"gh-desc__h2\">Studied mechanism of action<\/h2>\n\n    <h3 class=\"gh-desc__h3\">Triple GLP-1 \/ GIP \/ GCG agonism<\/h3>\n    <p class=\"gh-desc__text\">\n      GLP-3 RT simultaneously activates GLP-1 and GIP receptors, involved in appetite regulation and insulin secretion, as well as the glucagon (GCG) receptor, associated with stimulating lipolysis and increasing energy metabolism. This triple action combines anorexigenic effects, glycemic regulation, and increased energy expenditure.\n    <\/p>\n  <\/div>\n\n  <div class=\"gh-desc__section\">\n    <h2 class=\"gh-desc__h2\">Research areas<\/h2>\n\n    <h3 class=\"gh-desc__h3\">Obesity and weight management<\/h3>\n    <p class=\"gh-desc__text\">\n      Phase 2 trials reported body weight reductions of 22.8% and 24.2% at the 8 mg and 12 mg doses respectively over 48 weeks, accompanied by a decrease in BMI, waist circumference, as well as improvements in blood pressure and lipid profile.\n    <\/p>\n\n    <h3 class=\"gh-desc__h3\">TYPE 2 DIABETES<\/h3>\n    <p class=\"gh-desc__text\">\n      A mean HbA1c reduction of 2.16 percentage points at the 12 mg dose was observed, versus 0.43% under placebo. Weight loss of up to 16.94% (approximately 17.5 kg) was reported at the highest dose, with a downward trend maintained beyond week 36.\n    <\/p>\n\n    <h3 class=\"gh-desc__h3\">Metabolic hepatic steatosis<\/h3>\n    <p class=\"gh-desc__text\">\n      A reduction in liver fat volume of up to 82.4% at the 12 mg dose after 24 weeks was measured. Between 79% and 93% of participants achieved normalization of liver fat, with improvements in biomarkers of inflammation and liver injury.\n    <\/p>\n  <\/div>\n\n  <div class=\"gh-desc__section\">\n    <h2 class=\"gh-desc__h2\">Scientific references<\/h2>\n    <ul class=\"gh-desc__refs\">\n      <li><strong>Coskun T et al.<\/strong>, <em>Cell Metabolism<\/em>, 2022 ; 34(9):1234\u20131247 \u2014 caract\u00e9risation pharmacologique du triple agonisme GLP-1\/GIP\/GCG<\/li>\n      <li><strong>Jastreboff AM et al.<\/strong>, <em>New England Journal of Medicine<\/em>, 2023 ; 389(6):514\u2013526 \u2014 essai de phase 2 sur la r\u00e9duction du poids corporel<\/li>\n      <li><strong>Rosenstock J et al.<\/strong>, <em>The Lancet<\/em>, 2023 ; 402(10401):529\u2013544 \u2014 effets sur l'HbA1c et le contr\u00f4le glyc\u00e9mique dans le diab\u00e8te de type 2<\/li>\n      <li><strong>Sanyal AJ et al.<\/strong>, <em>Nature Medicine<\/em>, 2024 ; 30(7):2037\u20132048 \u2014 normalisation de la graisse h\u00e9patique et st\u00e9atose m\u00e9tabolique<\/li>\n    <\/ul>\n  <\/div>\n\n  <div class=\"gh-desc__disclaimer\">\n    This product is intended exclusively for laboratory research (Research Use Only). It is neither a medicine nor intended for human or animal consumption. The above information is derived from preclinical models or preliminary observations and does not constitute a therapeutic claim under any circumstances.\n  <\/div>\n\n<\/div>\n<\/div><\/div><\/div><\/div>\r\n\r\n<div class=\"et_pb_tab_1 et_pb_tab clearfix et_pb_module et_flex_module\"><div class=\"et_pb_tab_content et_flex_module\">\r\n\r\n<div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p>Votre contenu va ici. Modifiez ou supprimez ce texte en ligne ou dans les param\u00e8tres Contenu du module. Vous pouvez \u00e9galement styliser chaque aspect de ce contenu dans les param\u00e8tres Design du module et m\u00eame appliquer du CSS personnalis\u00e9 \u00e0 ce texte dans les param\u00e8tres Avanc\u00e9s du module.<\/p>\n<\/div><\/div><\/div><\/div>\r\n\r\n<div class=\"et_pb_tab_2 et_pb_tab clearfix et_pb_module et_flex_module\"><div class=\"et_pb_tab_content et_flex_module\">\r\n\r\n<div class=\"et_pb_code_1 et_pb_code et_pb_module\"><div class=\"et_pb_code_inner\" data-et-mv-hidden-tablet=\"true\">\n<\/div><\/div>\r\n\r\n<div class=\"et_pb_divider_0 et_pb_divider et_pb_space et_pb_divider_position_top et_pb_module\"><div class=\"et_pb_divider_internal\"><\/div><\/div>\r\n\r\n<div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_flex_module\"><div class=\"et_pb_text_inner\"><p><strong>Structure<\/strong><\/p>\n<\/div><\/div><\/div><\/div>\r\n\r\n<div class=\"et_pb_tab_3 et_pb_tab clearfix et_pb_module et_flex_module\"><div class=\"et_pb_tab_content et_flex_module\">\r\n\r\n<div class=\"et_pb_code_2 et_pb_code et_pb_module\"><div class=\"et_pb_code_inner\"><style>\n.gh-storage { font-family: 'Montserrat', sans-serif; max-width: 720px; }\n\n.gh-storage__section { margin-bottom: 32px; }\n\n.gh-storage__title {\n  font-size: 11px;\n  font-weight: 800;\n  letter-spacing: .08em;\n  text-transform: uppercase;\n  color: #393089;\n  margin: 0 0 10px;\n  padding-bottom: 8px;\n  border-bottom: 2px solid #E8E2F5;\n}\n\n.gh-storage__text {\n  font-size: 13px;\n  font-weight: 500;\n  color: #444455;\n  line-height: 1.8;\n  margin: 0;\n}\n\n.gh-storage__notice {\n  display: flex;\n  gap: 12px;\n  align-items: flex-start;\n  background: #FFF8F8;\n  border: 1px solid #FCCACA;\n  border-left: 4px solid #DC2626;\n  border-radius: 8px;\n  padding: 14px 16px;\n  margin-top: 28px;\n}\n\n.gh-storage__notice svg { flex-shrink: 0; margin-top: 1px; }\n\n.gh-storage__notice p {\n  font-size: 12px;\n  font-weight: 600;\n  color: #444455;\n  line-height: 1.7;\n  margin: 0;\n}\n\n.gh-storage__notice strong {\n  display: block;\n  font-size: 11px;\n  font-weight: 800;\n  letter-spacing: .06em;\n  text-transform: uppercase;\n  color: #DC2626;\n  margin-bottom: 4px;\n}\n<\/style>\n\n<div class=\"gh-storage\">\n\n  <div class=\"gh-storage__section\">\n    <p class=\"gh-storage__title\">Storage of lyophilized peptides<\/p>\n    <p class=\"gh-storage__text\">\n      Upon receipt, store the lyophilized peptide at 4 \u00b0C or below, protected from light and moisture. In lyophilized form, the product remains stable at room temperature for several weeks. For long-term storage, storage at -20 \u00b0C is strongly recommended. Moisture is the main degradation factor: before opening the vial, allow it to come to room temperature to avoid any condensation inside the container.\n    <\/p>\n  <\/div>\n\n  <div class=\"gh-storage__section\">\n    <p class=\"gh-storage__title\">Storage of reconstituted peptides<\/p>\n    <p class=\"gh-storage__text\">\n      Une fois en solution, la dur\u00e9e de conservation du peptide est limit\u00e9e. La cong\u00e9lation en aliquots permet d'en prolonger la stabilit\u00e9. De mani\u00e8re g\u00e9n\u00e9rale, un peptide reconstitu\u00e9 se conserve 3 semaines ou plus \u00e0 +4 \u00b0C, et 3 \u00e0 4 mois \u00e0 -20 \u00b0C. Il est imp\u00e9ratif d'\u00e9viter les cycles r\u00e9p\u00e9t\u00e9s de cong\u00e9lation\/d\u00e9cong\u00e9lation, qui d\u00e9gradent progressivement la structure du peptide. D\u00e9congeler uniquement la quantit\u00e9 n\u00e9cessaire \u00e0 chaque utilisation.\n    <\/p>\n  <\/div>\n\n  <div class=\"gh-storage__notice\">\n    <svg width=\"18\" height=\"18\" viewbox=\"0 0 20 20\" fill=\"none\">\n      <circle cx=\"10\" cy=\"10\" r=\"8.5\" stroke=\"#DC2626\" stroke-width=\"1.5\"\/>\n      <path d=\"M10 6v5\" stroke=\"#DC2626\" stroke-width=\"1.8\" stroke-linecap=\"round\"\/>\n      <circle cx=\"10\" cy=\"14\" r=\"0.8\" fill=\"#DC2626\"\/>\n    <\/svg>\n    <p>\n      <strong>Special case \u2014 TESAMORELIN<\/strong>\n      La T\u00e9samor\u00e9line ne suit pas les recommandations standard une fois reconstitu\u00e9e. En effet, elle doit \u00eatre conserv\u00e9e \u00e0 temp\u00e9rature ambiante, \u00e0 l'abri de la lumi\u00e8re et de la chaleur. De plus, elle doit imp\u00e9rativement \u00eatre consomm\u00e9e dans les <strong style=\"display:inline; font-size:inherit; text-transform:none; letter-spacing:0; color:#DC2626;\">7 days<\/strong> following dilution. Beyond this period, the product must no longer be used.\n    <\/p>\n  <\/div>\n\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p><strong>10mg CAS : 2381089-83-2<br \/><\/strong><\/p>","protected":false},"featured_media":257,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[24],"product_tag":[],"class_list":["post-256","product","type-product","status-publish","has-post-thumbnail","product_cat-weight-loss","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/product\/256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/comments?post=256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/media\/257"}],"wp:attachment":[{"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/media?parent=256"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/product_brand?post=256"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/product_cat?post=256"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/genhelixoptima.com\/en\/wp-json\/wp\/v2\/product_tag?post=256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}