BPC-157

Studied mechanisms of action

The scientific literature reports several pathways through which BPC-157 exerts its effects in preclinical research:

Cell proliferation

Stimulation of fibroblast proliferation and migration in culture and in vivo, in a dose- and time-dependent manner, promoting granulation tissue formation.

ERK1/2 signaling pathway

In chemical burn models, the peptide promoted re-epithelialization, dermal remodeling, and collagen deposition via activation of the ERK1/2 pathway.

Angiogenesis — VEGFR2

Stimulation of the membrane receptor VEGFR2, involved in the nitric oxide (NO) signaling pathway, promoting endothelial cell growth and collateral vessel formation.

FAK-paxillin pathway

In tendon healing studies, activation of the FAK-paxillin pathway was associated with increased fibroblast migration toward the injured site.

Research areas

Tissue healing

Acceleration of repair in various tissues: tendons, muscles, ligaments, joints, and skin.

Gastrointestinal protection

Documented cytoprotective effects on gastric ulcers, inflammatory bowel disorders, and intestinal hyperpermeability ("leaky gut").

Vascular effects

Accelerated restoration of blood supply to ischemic areas and activation of collateral vessel development in venous occlusion models.

Attenuation of drug side effects

Research suggesting reduction of catalepsy and gastric ulcers induced by neuroleptics, as well as protection against certain pharmacologically induced cardiac arrhythmias.

Antioxidant properties

Neutralization of oxidative stress markers (nitric oxide, malondialdehyde) and reduction of reactive oxygen species in the gastrointestinal tract.

Scientific references

• Huang et al., Drug Design, Development and Therapy, vol. 9, 2015 — mécanismes de cicatrisation sur brûlures alcalines (voie ERK1/2)
• Chang et al. — expression des récepteurs à l'hormone de croissance dans les fibroblastes tendineux
• Drmic et al., World Journal of Gastroenterology, vol. 24, n°48, 2018 — lésions du cæcum perforé et voie du monoxyde d'azote
• Multiples études — occlusion veineuse, colite, ischémie-reperfusion et compensation vasculaire
• Études sur la cicatrisation tendineuse — activation de la voie FAK-paxilline et migration des fibroblastes
• Škrlec et al., Applied Microbiology and Biotechnology, vol. 102, 2018 — systèmes de délivrance par Lactococcus lactis
• Strinic et al. et Jelovac et al. — arythmies cardiaques et effets secondaires liés aux neuroleptiques
• Tlak Gajger et al., Journal of Veterinary Pharmacology and Therapeutics, vol. 41, 2018 — traitement de la nosémose chez l'abeille domestique (Nosema ceranae)